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The dentate gyrus (DG) of the hippocampus is one of a few regions in the adult mammalian brain characterized by ongoing neurogenesis. CPZ also impaired glutamatergic signals and synaptic plasticity in the hippocampus.Klotho protected oligodendrocyte growth specifically in white matter.CPZ decreased mature oligodendrocytes in both cortical and white matter tissues.Multiple brain region-specific global gene expression profiling was performed.We examined developmental cuprizone (CPZ) neurotoxicity in maternally exposed rats.
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CPZ also reversibly targeted glutamatergic signals of GABAergic interneuron to affect dentate gyrus neurogenesis and synaptic plasticity in granule cells.
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Thus, developmental CPZ exposure reversibly decreased mature oligodendrocytes in both cortical and white matter tissues, and Klotho protected white matter oligodendrocyte growth. (SNL-NM), Albuquerque, NM (United States) Sponsoring Org.: USDOE National Nuclear Security Administration (NNSA) OSTI Identifier: 1328121 Report Number(s): SAND-2016-7558J Journal ID: ISSN 0027-8424 646387 TRN: US1700156 Grant/Contract Number: AC04-94AL85000 Resource Type: Accepted Manuscript Journal Name: Proceedings of the National Academy of Sciences of the United States of America Additional Journal Information: Journal Volume: 113 Journal Issue: 37 Journal ID: ISSN 0027-8424 Publisher: National Academy of Sciences, Washington, DC (United States) Country of Publication: United States Language: English Subject: 59 BASIC BIOLOGICAL SCIENCES dopamine channelrhodopsin-2 theta oscillation temporal difference = granule cells. Publication Date: Research Org.: Sandia National Lab.